This painting depicts the Madonna giving her girdle to St Thomas, with Sts Margaret, Gregory, Augustine, Raphael, and Tobias. There is a donor portrait of a kneeling nun, probably the abbess of Santa Margherita, a small Augustinian nunnery in Prato, where Fra Filippo was awarded the chaplaincy in 1456. Technical and stylistic evidence suggests that the picture was executed in two campaigns - designed and begun by Lippi and finished later by Fra Diamante.